Design, Development and In Vitro Characterization of Self Emulsifying Drug Delivery System for Irbesartan Design, Development and In-vitro Characterization of Self Emulsifying Drug Delivery System
Iranian Journal of Pharmaceutical Sciences,
Vol. 9 No. 2 (2013),
1 April 2013
,
Page 67-80
https://doi.org/10.22037/ijps.v9.40902
Abstract
The objectives of present investigations were to optimize concentration of oil, surfactant and cosurfactant by pseudoternary phase diagrams and to develop a stable formulation of self emulsifying drug delivery system (SEDDS) in order to enhance the dissolution rate of poorly soluble Irbesartan (IBS) by SEDDS. Pseudoternary phase diagrams were constructed to identify the self emulsifying region. Four self emulsifying formulations were prepared using mixture of Capryol 90 as oil, Tween 80 as surfactant and PEG 400 as cosurfactant in various proportions. Optimized liquid SEDDS formulations were converted into free flowing powder by spray drying technique and evaluated for drug content, infrared spectroscopy (FTIR), differential scanning colorimetry (DSC), powder X-ray diffraction (PXRD), Zeta potential analysis, Particle size analysis, scanning electron microscopy(SEM),in vitro dissolution study and in vitro diffusion study. The results suggested that considerabl improvement in the dissolution rate of drug from optimized SEDDS formulation was attributed to decreased crystallinity, altered surface morphology and reduction in particle size. Optimal formulation of irbesartan SEDDS were successfully developed in this work. The study illustrated that potential use of SEDDS dispense lipid soluble drug by oral route.
- Bioavailability
- Irbesartan
- Poor water solubility
- SEDDS
- Spray drying
- surfacnt
How to Cite
References
[2] Lipinski C. Poor aqueous solubility an industry wide problem in drug discovery. American Pharmaceutical Review ( 2002) 5: 82–85.
[3] Amidon G, Lennernas H, Shah V, Crison J. A theoretical basis for biopharmaceutical drug classification: the correlation of in vitro drug product dissolute on and in vivo bioavailability. Pharmaceutical Research (1995)12: 413–420.
[4] Serajuddin T. Solid dispersion of poorly water-soluble drugs: early promises, subsequent problems, and recent breakthroughs. Journal of Pharmaceutical Science (1999)88: 1058–1066.
[5] Veiga F, Fernandes C, Teixeira F. Oral bioavailability and hypoglycaemic activity of tolbutamide/cyclodextrin inclusion complexes. International Journal of Pharmaceutics (2000)202: 165–171.
[6] Kyatanwar A, Jadhav K, Kadam V. Self microemulsifying drug delivery system (SMEDDS): Review. Journal of Pharmaceutical Research ( 2010)3: 75-83.
[7] Lawrence M, Ress G. Microemulsion-based media as novel drug delivery systems. Advanced Drug Delivery Review (2000) 45: 89-121.
[8] Higuchi T and Connors K. Phase solubility techniques. Advances Analytical Chemistry and Instrumentation (1965) 4: 117-212.
[9] Abbaraju P, Meka A, Krishna M, Vijetha K. Formulation development of irbesartan (poorly water soluble drug) immediate release tablets. International Research Journal of Pharmacy (2012) 3(2): 117-120.
[10] Patravale V, Bachhav Y. SMEDDS of Glyburide: formulated, in vitro evaluation, and stability studies. American Association of Pharmaceutical Science (2009)10 (2): 482-487.
[11] Hong J, Kim J, Song Y, Park J, Kim C. A new self- emulsifying formulation of intraconazole with improved dissolution and oral absorption. Journal of Controlled Release (2006) 110: 332-338
[12] Setthacheewakul S, Mahattanadul S, Phadoongsombut N, Pichayakorn W,Wiwattanapatapee R.. Development and evaluation of self-microemulsifying liquid and pellet formulations of curcumin, and absorption studies in rats. European Journal of Pharmaceuticsand Biopharmaceutics (2010)76: 475-485.
[13] Gursoy R, Benita S. Selfemulsifying drug delivery systems (SEDDS) for improved oral delivery of lipophilic drugs. Biomedicine and Pharmacotherapy (2004)58: 73– 182.
[14] Dixit A, Rajput S, Patel S. Preparation and bioavailability assessment of SMEDDS containing Valsartan. American Association of Pharmaceutical Science ( 2009) 11(1): 314-321.
[15] Shanmugam S, Baskaran R, Balakrishnan P, Thapa P, Yong C, Yoo B. Solid self- nanoemulsifying drug delivery system (S-SNEDDS) containing phosphatidylcholine for enhanced bioavailability of highly lipophilic bioactive carotenoid lutein. European Journal of Pharmaceutics and Biopharmaceutics (2011)79:250-257.
[16] Nekkanti V, Karatgi P, Prabhu R, Pillai R. Solid Self-microemulsifying formulation for candesartan Cilexetil. American Association of Pharmaceutical Science (2009) 1-9.
[17] Shete A, Yadav A, Murthy M. Enhancement of dissolution rate of Irbesartan by chitosan based crystal engineering technique. Indian Journal of Pharmaceutical Education Research (2012) 46(4):323-329.
[18] Chatwal G, Anand S. Instrumental Methods of Chemical Analysis, 1st ed., Himalaya Publishing House: Mumbai ( 2009).
[19] http:// www.permegear.com
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