Transdermal Delivery of Insulin by Biodegradable Chitosan Nanoparticles: Exvivo and In vivo Studies Transdermal delivery of insulin
Iranian Journal of Pharmaceutical Sciences,
Vol. 8 No. 1 (2012),
15 January 2012
,
Page 315-321
https://doi.org/10.22037/ijps.v8.41002
Abstract
Insulin-loaded biodegradable chitosan nanoparticle was prepared by the polyelectrolyte complex formation method. The prepared nanoparticles were in the size of 110 nm and had high entrapment (91.0%) capacity. The transdermal nanoinsulin was characterized by in vivo hypoglycemic effects. Plasma glucose was decreased to the range of 80.34 to 96.74 mg/dl, and insulin levels were increased to the range of 21.62
to 45.80 μIU/ml for up to 60 h. The pharmacokinetic and pharmacodynamic parameters like AUC, Cmax, Tmax and relative bioavailability of transdermal patch loaded insulin-chitosan nanoparticles were 3153.36 μIU/ml/h, 45.80 μIU/ml, 8 h and 20.02%, respectively.
- Bioavailability
- Diabetes
- in vivo studies
- Insulin
- Nanoparticle
How to Cite
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