Aminophylline Infusion Induced Excretion of Magnesium DuringMagnesium Loading Test in Critically Ill Patients Aminophylline induced excretion of magnesium
Iranian Journal of Pharmaceutical Sciences,
Vol. 3 No. 4 (2007),
1 October 2007
,
Page 191-196
https://doi.org/10.22037/ijps.v3.41019
Abstract
The aim of this study was to investigate the prevalence of Mg deficiency and effectof aminophylline infusion on urine magnesium concentration after magnesiumloading test (MLT). To determine serum Mg, venous blood specimens were obtainedjust before the first MLT. Two MLTs were performed. The first one was donebefore starting aminophylline infusion and the 2ndone was done during aminophyllineinfusion. Urine samples were collected from the starting of Mg infusion in each phase.Although low serum Mg was present only in 2 patients, MLTshowed Mg deficiencyin 18 patients. MLTdetected Mg deficiency in 13 out of 14 patients with normalserum Mg, in 2 out of 2 subjects with serum hypomagnesemia, and in 3 out of 5 caseswith serum hypomagnesemia. There was no relationship between Mg retention, ageand serum Mg concentrations. Aminophylline administration increased the 24-h urineMg concentration by 29.3%.
- Aminophylline
- Critically ill
- Hypomagnesaemia
- Magnesium LoadingTest
- Theophylline
How to Cite
References
[2]Ronald EJ. Magnesium metabolism in health anddisease. Disease Manth1998; 34: 161-218.
[3]Salem M, Munoz R, Chernow B.Hypomagnesemia in critical illness. Crit CareClin1991; 7: 225-52.
[4]Arsenia MA. Magnesium and cardiovasculardisease. Prog Cardiovasc Dis1993; 35: 271-310.
[5]Kingston ME, Al-Sibai MB, Skooge WC. Clinicalmanifestations of hypomagnesemia. Crit CareMed1986; 14: 950-4.
[6]Al-Ghamdi SM, Cameron EC, Sutton RA.Magnesium deficiency: Pathophysiologic andclinical overview. Am J Kidney Dis1994; 24:737-52.
[7]Olerich MA, Rude RK. Should we supplementmagnesium in critically ill patients? New Horiz1994; 2: 186-92.
[8]Lim P, Jacob E. Tissue magnesium level in chronicdiarrhea. J Lab Clin Med1972; 80: 313-31.
[9]Whang R, Ryder KW. Frequency ofhypomagnesemia and hypermagnesemia:requested vs routine.JAMA1990; 263: 3063-4.
[10]Wong ET, Rude RK, Singer FR, Shaw STJr. Ahigh prevalence of hypomagnesemia and hyper-magnesemia in hospitalized patients.Am J ClinPathol1983; 79: 348-52.
[11]Rubeiz GJ, Thill-Baharozian M, Hardie D,Carlson RW. Association of hypomagnesemiaand mortality in acutely ill medical patients. CritCare Med1993; 21: 203-9.
[12]Reinhart RA, Desbiens NA. Hypomagnesemia inpatients entering the ICU. Crit Care Med 1985;13: 506-7.
[13]Ryzen E, Wagers PW, Singer FR, Rude RK.Magneseium deficiency in medical ICUpopulation.Crit Care Med1985; 13: 19-21.
[14]Kohls PR, Townsend PL, Markowsky SJ. Phar-macokinetics and dosing of theophylline. In:Rippe JM, (editor).Intensive care medicine, 2nded. New York; 1991. pp. 1748-53.
[15]Flack JM, Ryder KW, Strickland D, Whang R.Metabolic correlates of theophylline therapy: Aconcentration-related phenomenon. AnnalsPharmacother1994; 28: 175-9.
[16]Hebert P, Mehta N, Wang J, Hindmarsh T, JonesG, Cardinal P. Functional magnesium deficiencyin critically ill patients identified using amagnesium-loading test. Crit Care Med1997;25: 749-55.
[17]Gullestad L, Midtvedt K. The magnesium loadingtest: Reference values in healthy subjects. ScandJ Clin Lab Invest1994; 54: 23.
[18]Gullestad L, Dolva L, Waage A, Falch D,Fagerthum H, Kjekshus J. Magnesium deficiencydiagnosed by an intravenous loading test. ScandJ Clin Lab Invest1992; 52: 245-53.
[19]Rob PM, Dick K, Bley N, Seyfert T, BrinckmannC, Hollriegel V, Friedrich HJ, Dibbelt L, SeeligMS. Can one really measure magnesiumdeficiency using the short-term magnesiumloading test? J Inter Med 1999; 246: 373-8.
[20]Papazachariou IM, Martinez-Isla A, EfthimiorE, Williamson RC, Giris SI. Magnesiumdeficiency in patients with chronic pancreatitisidentified by an intravenous loading test. ClinicaChimica Acta 2000; 302: 145-54.
[21]Sohrevardi SM, Mojtahedzadeh M, Sadray S,Najafi A, Spence JD, Munoz C, Tavakoli H. Thevalue of aminophylline dosing based on phar-macokinetic variables in the critically ill patients.J Medical Council IRI2004; 22: 28-31.
[22]Polderman KH, Bloemers FW, Peerdeman S,Girbes ARJ. Hypomagnesemia and hypophos-phatemia at admission in patients with severehead injury. Crit Care Med2000; 28: 2022-5.
[23]Pretzlaff RK, Vardis RJ, Pollack MM.Aminophylline in the treatment of fluid overload.Crit Care Med1999; 27: 787-90.
[24]Rayssiguier Y. Hypomagnesemia resulting fromadrenaline infusion in ewes: Its relation tolipolysis. Horm Metab Res 1997; 9: 309-14.
[25]Knutsen R, Bohmer T, Falch J. Intravenoustheophylline-induced excretion of calcium,magnesium and sodium in patients with recurrent asthmatic attacks. Scand J Clin Lab Invest1994;54: 119-25.
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