Studies on the Charge-TransferInteraction Between TamoxifenCitrate and Chloranilic Acid Charge-transfer between tamoxifen and chloranilic acid
Iranian Journal of Pharmaceutical Sciences,
Vol. 3 No. 4 (2007),
1 October 2007
,
Page 203-208
https://doi.org/10.22037/ijps.v3.41022
Abstract
The complex formed as a consequence of the interaction between the electron-acceptor P-chloranilic acid and an electron donor tamoxifen citrate was employedin the assay of the drug in pure powder and tablets. Chloranilic acid was found toform a charge-transfer complex in a 1:1 stoichiometric ratio, with tamoxifen citrate.The wavelength of maximum absorption for the complex was found to be 550 nmwhile the absorbance was linear over the concentration range of 2-100 g/ml.Evaluations of the various thermodynamic parameters by means of the Scottequation was carried out and were found to decrease with increase in temperature.The free energy change (ΔG°) and the enthalpy of formation (ΔH°) as well as theentropy (ΔS°) were determined for various interactions. Results obtained suggestthat the proposed method may be conveniently applied in the analysis ofcommercially available tamoxifen citrate tablets with a high degree of accuracy andreproducibility.
- Charge-transfer complexation
- Chloranilic acid
- Tamoxifen citrate
- Thermodynamic studies
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References
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