Anti-Inflammatory Activity of a Selection of Antidepressant Drugs Kaempferol 3-O-glycoside from Tribulus terrestris L.
Iranian Journal of Pharmaceutical Sciences,
Vol. 4 No. 3 (2008),
1 July 2008
,
Page 225-230
https://doi.org/10.22037/ijps.v4.41134
Abstract
Anti-inflammatory activity has been reported for a few of antidepressant drugs and in contrary sertraline has potentiated inflammation. In this study, anti-inflammatory effect of a collection of antidepressant drugs belonging to different classes was evaluated to help a rational selection of these drugs in disease conditions such as association of depression or anxiety with inflammatory diseases such as rheumatoid arthritis. Male Wistar rats weighing 160-200 g were used. Anti-inflammatory activity was assessed using carrageenan-induced paw edema test.Amitriptyline, nortriptyline, desipramine, trimipramine, fluvoxamine (37.5 and 75mg/kg), fluoxetine (30 and 60 mg/kg), citalopram (10 and 40 mg/kg), doxepin and maprotiline (25 and 50 mg/kg) were administered s.c. 30 min. prior to subplantar injection of 100 µl carrageenan suspension (1% w/v). Difference of paw volume measured just before and 4 h after carrageenan injection was considered as an index of inflammation. Except nortriptyline and citalopram, all tested drugs showed anti-inflammatory activity. It seems that the anti-inflammatory effect is not correlated with inhibition of norepinephrine and/or serotonin reuptake transporters and further studies are needed to clarify the exact mechanism of their anti-inflammatory action.
- Antidepressants
- Anti-inflammatory
- Carrageenan.
How to Cite
References
[2]Coquoz D, Porchet HC, Dayer P. Central analgesic effects of antidepressant drugs with various mechanisms of action: Desipramine, fluvoxamine and moclobemide. Schweiz Med Wochenschr 1991; 121: 1843-5.[3]Korzeniewska-Rybicka I, Plaznik A. Analgesic effect of antidepressant drugs. Pharmacol Biochem Behav1998; 59: 331-8.
[4]Korzeniewska-Rybicka I, Plaznik A.Supraspinally mediated analgesic effect of antidepressant drugs. Pol J Pharmacol 2000; 52:93-9.
[5]Ganvir P, Beaumont G, Seldrup J. Acomparative trial of clomipramine and placebo as adjunctive therapy in arthralgia. J Int Med Res1980; 8: 60-6.
[6]McHenry JJ. Antidepressant and analgesic treatment in osteoarthritis and similar disorders.J Am Osteopath Assoc1959; 58: 422-4.
[7]Perahia DG, Pritchett YL, Desaiah D, Raskin J.Efficacy of duloxetine in painful symptoms: An analgesic or antidepressant effect?Int Clin Psy-chopharmacol2006; 21: 311-7.
[8]Sindrup SH, Brosen K, Gram LF. Antidepres-sants in pain treatment: Antidepressant or analgesic effect? Clin Neuropharmacol1992;15: 636A-7A.
[9]Abdel-Salam OM, Nofal SM, ElShenawy SM.Evaluation of the anti-inflammatory and anti-nociceptive effects of different antidepressants in the rat. Pharmacol Res 2003; 48: 157-65.
[10]Abdel-Salam OM, Baiuomy AR, Arbid MS.Studies on the anti-inflammatory effect of fluoxetine in the rat. Pharmacol Res2004; 49:119-31.
[11]Bianchi M, Rossoni G, Sacerdote P, Panerai AE,Berti F. Effects of chlomipramine and fluoxetine on subcutaneous carrageenin-inducedinflammation in the rat.Inflamm Res 1995; 44:466-9.
[12]Michelson D, Misiewicz-Poltorak B, Raybourne RB, Gold PW, Sternberg EM. Imipramine reduces the local inflammatory response to carrageenin.Agents Actions1994; 42: 25-8.
[13]Tangri KK, Saxena PR, Seth PK, Bhargava KP.Anti-inflammatory activity of imipramine and congeners. Biochem Pharmacol 1966; 15: 825-31.
[14]Baldessarini RJ. Drug therapy of depression and anxiety disorders. In: Brunton LL, Lazo JS, Parker KL, (editors). Goodman and Gilmans the phar-macological basis of therapeutics. New York:McGraw- Hill, 2006; pp. 429-59.
[15]Kast RE. Anti- and pro-inflammatory considerations in antidepressant use during medical illness: Bupropion lowers and mirtazapine increases circulating tumor necrosis factor-alphalevels. Gen Hosp Psychiatry 2003; 25: 495-6.
[16]Nelson JC. Areview of the efficacy of serotonergic and noradrenergic reuptake inhibitors for treatment of major depression.Biol Psychiatry 1999; 46: 1301-8.
[17]Gastpar M. Clinical originality and new biology of trimipramine. Drugs1989; 38: 43-8.
[18]Winter CA, Risley EA, Nuss GW. Carrageenin-induced edema in hind paw of the rat as an assay for antiiflammatory drugs. Proc Soc Exp Biol Med1962; 111: 544-7.
[19]Bianchi M, Sacerdote P, Panerai AE. Fluoxetine reduces inflammatory edema in the rat:Involvement of the pituitary-adrenal axis. Eur J Pharmacol1994; 263: 81-4.
[20]Faraj BA, Olkowski ZL, Jackson RT. Expression of a high-affinity serotonin transporter in human lymphocytes.Int J Immunopharmacol 1994; 16:561-7.
[21]Marino F, Cosentino M, Bombelli R, Ferrari M,Lecchini S, Frigo G. Endogenous catecholamine synthesis, metabolism storage, and uptake in human peripheral blood mononuclear cells. ExpHematol1999; 27: 489-95.
[22]Elenkov IJ, Wilder RL, Chrousos GP, Vizi ES. The sympathetic nerve-an integrative interface between two supersystems: The brain and the immune system. Pharmacol Rev 2000; 52: 595-638.
[23]Bianchi M, Sacerdote P, Panerai AE.Clomipramine differently affects inflammatory edema and pain in the rat. Pharmacol Biochem1994; 48: 1037-40.
[24]Di Rosa M, Giroud JP, Willoughby DA. Studies of the mediators of the acute inflammatory response induced in rats in different sites by carrageenan and turpentine. J Pathol 1971; 104:15-29.
[25]Di Rosa M. Biological properties of carrageenan.J Pharm Pharmacol1972; 24: 89-102.
[26]Vinegar R, Truax JF, Selph JL, Johnston PR,Venable AL, Mckenzie KK. Pathway to carrageenan-induced inflammation in the hind limb of the rat. Fed Proc1987; 46: 118-26.
[27]Ezeamuzie CI, Umezurike CC. Effect of histamine H2-receptor antagonists on acute inflammatory ofthe rat paw oedema. J Pharm Pharmacol 1989;41: 261-5.
[28]Alvarez FJ, Casas E, Franganillo A, Velasco A.Effects of antidepressants on histamine H2 receptors in rat isolated uterus. J Pharmacol 1986; 17: 351-4.
[29]Shen WW, Mahadevan J, Hofstatter L, Sata LS.Doxepin as a potent H2and H2antihistamine for epigastric distress. Am J Psychiatry1983; 140:957-8.
- Abstract Viewed: 344 times
- IJPS_Volume 4_Issue 3_Pages 225-230 Downloaded: 242 times