Low Dose Morphine Enhances Morphine Antinociception Effectsin the Animals Pretreated with Selective and Non-Selective Phosphodiestrase Inhibitors Effects of phosphodiesterase inhibitors on morphine antinociception
Iranian Journal of Pharmaceutical Sciences,
Vol. 5 No. 2 (2009),
1 April 2009
,
Page 73-81
https://doi.org/10.22037/ijps.v5.41189
Abstract
In this study, we investigated the interactive effects of intraperitoneal (i.p.)injections of three different phosphodiesterase inhibitors (PDEIs) on morphine-induced analgesia in mice using tail-flick method. Subcutaneous administration of morphine (1, 3 and 6 mg/kg) caused significant antinociceptive effects in a dose dependent manner. Administration of pentoxifylline (12.5, 25, 50 and 100 mg/kg,i.p.), milrinone (3 and 4.5 mg/kg, i.p.) and theophylline (25, 50 and 100 mg/kg, i.p.)as selective and non-seletive phosphodiesterase in hibitors in duced analgesia inmice. We also examined the antinociceptive effects of these three PDEIs incombination with non-effective dose of morphine (1 mg/kg). These combinations increased analgesia effects compared to the either morphine or respective phospho-diestrase inhibitor groups significantly. Our findings strongly suggest that PDEIs can induce analgesia and potentiate morphine antinociception effect via possible interactions on the same molecular or biochemical pathways.
Keywords:
- Antinociception
- Milrinone
- Morphine
- Pentoxifylline
- Phosphodiesterase inhibitors
- Thermal hyperalgesia
How to Cite
Mohammad Hassan Karimfar, Shervin Gholizadeh, Amir Peyman Hajrasouliha, Kaveh Tabrizian, Kian Azami, Mohammad Abdollahi, … Abdol Hossain Miri. (2009). Low Dose Morphine Enhances Morphine Antinociception Effectsin the Animals Pretreated with Selective and Non-Selective Phosphodiestrase Inhibitors: Effects of phosphodiesterase inhibitors on morphine antinociception. Iranian Journal of Pharmaceutical Sciences, 5(2), 73–81. https://doi.org/10.22037/ijps.v5.41189
References
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[24]Gonzalez-Cuello A, Sanchez L, Hernandez J,Teresa Castells M, Victoria Milanes M, Laorden ML. Phosphodiesterase 4 inhibitors, rolipram and diazepam block the adaptive changes observed during morphine withdrawal in the heart. Eur J Pharmacol2007; 570: 1-9.
[25]Wang JF, Khasar SG, Ahlgren SC, Levine JD.Sensitization of c-fibres by prostaglandin E2 in the rat is inhibited by guanosine 5'-O-(2-thiodiphos-phate), 2',5'-dideoxyadenosine and walsh inhibitor peptide.Neuroscience1996; 71: 259-63.
[26]Yanai Y, Hashitani H, Hayase M, Sasaki S, SuzukiH, Kohri K. Role of nitric oxide/cGMP pathway in regulating spontaneous excitations in detrusor smooth muscle of the guinea-pig bladder.Neurourol Urodyn2008; 27: 446-53.
[27]Moro MA, Russel RJ, Cellek S, Lizasoain I, SuY, Darley-Usmar VM, Radomski MW, Moncada S. cAMPmediates the vascular and platelet actions of nitric oxide. Confirmation using an inhibitor of the soluble guanylyl cyclase. Proc Natl Acad Sci USA1996; 93: 1480-5.
[28]Haley JE, Dickenson AH, Schachter M. Electro-physiological evidence for a role of nitric oxide in prolonged chemical nociception in the rat.Neuropharmacology1992; 31: 251-8.
[29]Kawabata A, Manabe S, Manabe Y, Takagi H.Effect of topical administration of L-arginine on formalin-induced nociception in the mouse: A dual role of peripherally formed NO in pain modulation. Br J Pharmacol1994; 112: 547-50.
[30]Malmberg AB, Yaksh TL. Spinal nitric oxide synthesis inhibition blocks nmda-induced thermal hyperalgesia and produces antinociception in the formalin test in rats. Pain1993; 54: 291-300.
[31]Morgan CV, Babbedge RC, Gaffen Z, Wallace P,Hart SL, Moore PK. Synergistic anti-nociceptive effect of L-NG-nitro arginine methyl ester (L-NAME) and flurbiprofen in the mouse. Br J Pharmacol1992; 106: 493-7.
[32]Mustafa AA. Mechanisms of L-NG-nitro arginine methyl ester-induced antinociception in mice: A role for serotonergic and adrenergic neurons. Gen Pharmacol1992;23:1177-1182.
[2]Dal Piaz V, Giovannoni MP. Phosphodiesterase 4 inhibitors, structurally unrelated to rolipram, as promising agents for the treatment of asthma and other pathologies. Eur J Med Chem 2000; 35: 463-80.
[3]Jain NK, Patil CS, Singh A, Kulkarni SK.Sildenafil, a phosphodiesterase-5 inhibitor,enhances the antinociceptive effect of morphine.Pharmacology2003; 67: 150-6.
[4]Tao YX, Hassan A, Haddad E, Johns RA.Expression and action of cGMP-dependent protein kinase alpha in inflammatory hyperalgesia in rat spinal cord. Neuroscience2000; 95: 525-33.
[5]Durate ID, Lorenzetti BB, Ferreira SH. Peripheral analgesia and activation of the nitric oxide-cGMPpathway. Eur J Pharmacol 1990; 186: 289-93.
[6]Kress M, Rodl J, Reeh PW. Stable analogues of cAMPbut not cGMPsensitize unmyelinated primary afferents in rat skin to heat stimulation but not to inflammatory mediators, in vitro.Neuroscience1996; 74: 609-17.
[7]Taiwo YO, Levine JD. Further confirmation of the role of adenyl cyclase and of cAMP-dependent protein kinase in primary afferent hyperalgesia.Neuroscience1991; 44: 131-5.
[8]Cunha FQ, Teixeira MM, Ferreira SH. Pharma-cological modulation of secondary mediator systems--cAMPand cGMP--on inflammatory hyperalgesia. Br J Pharmacol 1999; 127: 671-8.
[9]Bernstein MA, Welch SP. Effects of spinal versussupraspinal administration of cyclic nucleotide-dependent protein kinase inhibitors on morphinetolerance in mice. Drug Alcohol Depend1997; 44:41-6.[10]Burton CK, Ho IK, Hoskins B. Evidence for involvement of cGMPphosphodiesterase in morphine tolerance. J Pharmacol Exp Ther1990;252: 104-1.
[11]Mamiya T, Noda Y, Ren X, Hamdy M, Furukawa S, Kameyama T, Yamada K, Nabeshima T.Involvement of cAMPsystems in morphine physical dependence in mice: Prevention of development of morphine dependence by rolipram, a phosphodiesterase 4 inhibitor. Br JPharmacol2001; 132: 1111-7.
[12]Galeotti N, Ghelardini C, Bartolini A. Effect of pertussis toxin on morphine, diphenhydramine,baclofen, clomipramine and physostigmine antinociception. Eur J Pharmacol1996; 308:125-33.
[13]Galeotti N, Ghelardini C, Bartolini A. The role of potassium channels in antihistamine analgesia.Neuropharmacology1999; 38: 1893-901.
[14]Hawes BE, Fried S, Yao X, Weig B, Graziano MP.Nociceptin (orl-1) and mu-opioid receptors mediate mitogen-activated protein kinase activation in cho cells through a gi-coupled signaling pathway: Evidence for distinct mechanisms of agonist-mediated desensitization.J Neurochem1998; 71: 1024-33.
[15]Shah S, Breivogel C, Selly D, Munirathinam G,Childers S, Yoburn BC. Time-dependent effects of in vivopertussis toxin on morphine analgesia and g-proteins in mice. Pharmacol Biochem Behav1997; 56: 465-9.[16]Womer DE, DeLapp NW, Shannon HE.Intrathecal pertussis toxin produces hyperalgesia and allodynia in mice. Pain1997; 70: 223-8.
[17]Mixcoatl-Zecuatl T, Aguirre-Banuelos P,Granados-Soto V. Sildenafil produces antinocicep-tion and increases morphine antinociception in the formalin test. Eur J Pharmacol2000; 400: 81-7.
[18]Yoon MH, Choi JI, Kim SJ, Kim CM, Bae HB,Chung ST. Synergistic antinociception between zaprinast and morphine in the spinal cord of rats on the formalin test. Eur J Anaesthesiol2006; 23:65-70.
[19]Ouseph AK, Khasar SG, Levine JD. Multiple second messenger systems act sequentially to mediate rolipram-induced prolongation of prostaglandin E2-induced mechanical hyperalgesia in the rat. Neuroscience1995; 64:769-76.
[20]Raghavendra V, Tanga FY, DeLeo JA. Attenuation of morphine tolerance, withdrawal-induced hyperalgesia, and associated spinal inflammatory immune responses by propentofylline in rats.Neuropsychopharmacology2004; 29: 327-34.
[21]Sweitzer SM, Schubert P, DeLeo JA. Propento-fylline, a glial modulating agent, exhibits antiallodynic properties in a rat model of neuropathic pain. J Pharmacol Exp Ther2001;297: 1210-7.
[22]Wordliczek J, Szczepanik AM, Banach M,Turchan J, Zembala M, Siedlar M, Przewlocki R,Serednicki W, Przewlocka B. The effect of pentoxifiline on post-injury hyperalgesia in rats and postoperative pain in patients. Life Sci 2000;66: 1155-64.
[23]Itoh A, Noda Y, Mamiya T, Hasegawa T,Nabeshima T. Atherapeutic strategy to prevent morphine dependence and tolerance by coadmin-istration of camp-related reagents with morphine.Methods Find Exp Clin Pharmacol1998; 20:619-25.
[24]Gonzalez-Cuello A, Sanchez L, Hernandez J,Teresa Castells M, Victoria Milanes M, Laorden ML. Phosphodiesterase 4 inhibitors, rolipram and diazepam block the adaptive changes observed during morphine withdrawal in the heart. Eur J Pharmacol2007; 570: 1-9.
[25]Wang JF, Khasar SG, Ahlgren SC, Levine JD.Sensitization of c-fibres by prostaglandin E2 in the rat is inhibited by guanosine 5'-O-(2-thiodiphos-phate), 2',5'-dideoxyadenosine and walsh inhibitor peptide.Neuroscience1996; 71: 259-63.
[26]Yanai Y, Hashitani H, Hayase M, Sasaki S, SuzukiH, Kohri K. Role of nitric oxide/cGMP pathway in regulating spontaneous excitations in detrusor smooth muscle of the guinea-pig bladder.Neurourol Urodyn2008; 27: 446-53.
[27]Moro MA, Russel RJ, Cellek S, Lizasoain I, SuY, Darley-Usmar VM, Radomski MW, Moncada S. cAMPmediates the vascular and platelet actions of nitric oxide. Confirmation using an inhibitor of the soluble guanylyl cyclase. Proc Natl Acad Sci USA1996; 93: 1480-5.
[28]Haley JE, Dickenson AH, Schachter M. Electro-physiological evidence for a role of nitric oxide in prolonged chemical nociception in the rat.Neuropharmacology1992; 31: 251-8.
[29]Kawabata A, Manabe S, Manabe Y, Takagi H.Effect of topical administration of L-arginine on formalin-induced nociception in the mouse: A dual role of peripherally formed NO in pain modulation. Br J Pharmacol1994; 112: 547-50.
[30]Malmberg AB, Yaksh TL. Spinal nitric oxide synthesis inhibition blocks nmda-induced thermal hyperalgesia and produces antinociception in the formalin test in rats. Pain1993; 54: 291-300.
[31]Morgan CV, Babbedge RC, Gaffen Z, Wallace P,Hart SL, Moore PK. Synergistic anti-nociceptive effect of L-NG-nitro arginine methyl ester (L-NAME) and flurbiprofen in the mouse. Br J Pharmacol1992; 106: 493-7.
[32]Mustafa AA. Mechanisms of L-NG-nitro arginine methyl ester-induced antinociception in mice: A role for serotonergic and adrenergic neurons. Gen Pharmacol1992;23:1177-1182.
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