Preparation and Evaluation of Cyproterone Acetate LiposomeforTopical Drug Delivery Cyproterone acetate liposome for topical drug delivery
Iranian Journal of Pharmaceutical Sciences,
Vol. 5 No. 4 (2009),
1 October 2009
,
Page 199-204
https://doi.org/10.22037/ijps.v5.41223
Abstract
Cyproterone acetate (CA) has been loaded to liposome by solvent evaporation and thin film formation technique. The effects of some formulation variables such as temperature of organic solvent evaporation, rotary evaporator speed, volume of organic solvent, volume of balloon and temperature of hydrating buffer has been evaluated. The data showed that bigger balloon with higher surface area has better capacity for lipidic film formation; also the best temperature for solvent evaporation and film hydration was 40 °C. According to the data with higher drug/lipid ratio,it is possible to load higher amount of drug into liposome but optimum loading could be obtained at phosphatidylcholine (PC): cholesterol/drug ratio of 1:2:0.5 (with maximum 74±6.11% loading efficiency). Finally percutaneous absorption of CA from simple gel and liposomal formulations was assessed. The results showed that liposomal formulation has better penetration potential than conventional CAformulation (simple gel).
- Cyproterone acetate
- Liposome
- Percutaneous absorption
How to Cite
References
[2]Kriwet K, Muller-Goymann CC. Diclofenacrelease from phospholipid drug systems and permeation through excised human stratum corneum. Internat J Pharm1995; 125: 231-42.
[3]Lener EV, Bucalo BD, Kist DA, Moy RL. Topical anesthetic agents in dermatologic surgery. Areview. Dermatol Surg1997; 23: 673-83.
[4]Esposito E, Zanella C, Cortesi R, Menegatti E,Nastruzzi C. Influence of liposomal formulation parameters on the in vitroabsorption of methyl nicotinate.Internat J Pharm1998; 172: 255-60.
[5]Gruber D. Hormonal therapy against aging skin,hirsutism and hair loss. Wie Haut und Haare von Hormonen Profitieren 1998; 9: 29-33.
[6]Gruber DM, Sator MO, Joura EA, Kokoschka EM, Heinze G, Huber JC. Topical cyproterone acetate treatment in women with acne: Aplacebo-controlled trial. Arch Dermatol1998; 134: 459-63.
[7]Fang JY, Hong CT, Chiu WT, Wang YY. Effect of liposomes and niosomes on skin permeation of enoxacin.Internat J Pharm2001; 219: 61-72.
[8]Naeff R. Feasibility of topical liposome drugs produced on an industrial scale. Advanced Drug Delivery Rev1996; 18: 343-7.
[9]Barnadas-Rodriguez R, Sabes Xamani M.Liposomes prepared by high-pressure homogenizers. Methods Enzymol2003; 367: 28-46.
[10]Barnadas-Rodriguez R, Sabes M. Factors involved in the production of liposomes with a high-pressure homogenizer. Internat J Pharm2001;213: 175-86.
[11]Manosroi A, Kongkaneramit L, Manosroi J.Stability and transdermal absorption of topical amphotericin B liposome formulations. Internat J Pharm2004; 270: 279-86.
[12]Manosroi A, Podjanasoonthon K, Manosroi J.Development of novel topical tranexamic acid liposome formulations. Internat J Pharm2002;235: 61-70.
[13]Schwendener RA. Liposomes in biology and medicine. Adv Exp Med Biol2007; 620: 117-28.
[14]Samad A, Sultana Y, Aqil M. Liposomal drug delivery systems: An update review. Curr Drug Deliv2007; 4: 297-305.
[15]Dass CR. Drug delivery in cancer using liposomes. Methods Mol Biol2008; 437: 177-82.
[16]Wang JT, Peng DY, Chen M, Ye JS. Gene delivery for lung cancer using nonviral gene vectors.Pharmazie2007; 62: 723-6.
[17]Bonina FP, Montenegro L, Scrofani N, Esposito E, Cortesi R, Menegatti E, Nastruzzi C. Effects of phospholipid based formulations on in vitro and in vivo percutaneous absorption of methyl nicotinate. J Control Release 1995; 34: 53-63.
[18]Dayan N, Touitou E. Carriers for skin delivery of trihexyphenidyl HCl: Liposomes vs.ethosomes.Proceedings Controlled Release Society1999:443-4.
[19]Dayan N, Touitou E. Carriers for skin delivery of trihexyphenidyl HCl: Ethosomes vs.liposomes.Biomaterials2000; 21: 1879-85.
[20]Law SL, Hung HY. Properties of acyclovir-containing liposomes for potential ocular delivery.Internat J Pharm1998; 161: 253-9.
[21]Agarwal R, Katare OP, Vyas SP. Preparation and in vitroevaluation of liposomal/niosomal delivery systems for antipsoriatic drug dithranol. Internat J Pharm2001; 228: 43-52.
[22]Valenta C, Janisch M. Permeation of cyproterone acetate through pig skin from different vehicles with phospholipids. Int J Pharm 2003; 258: 133-9.203
- Abstract Viewed: 385 times
- IJPS_Volume 5_Issue 4_Pages 199-204 Downloaded: 308 times