Phytosome: Drug Delivery System for Polyphenolic Phytoconstituents Phytosome
Iranian Journal of Pharmaceutical Sciences,
Vol. 7 No. 4 (2011),
1 October 2011
,
Page 209-219
https://doi.org/10.22037/ijps.v7.41292
Abstract
Several plant extracts and phytoconstituents, despite having excellent bioactivity in vitro, demonstrate less or no in vivo actions due to their poor lipid solubility or improper molecular size or destruction in gut. Drug delivery system for polyphenolic phytoconstituents (phytosomes) was prepared by complexing polyphenolic phyto phytoconstituents (phytosomes) was prepared by complexing polyphenolic phyto to each other on a molecular level. Bioavailability is enhanced due to their capacity to each other on a molecular level. Bioavailability is enhanced due to their capacity to each other on a molecular level. Bioavailability is enhanced due to their capacity have the capacity to deliver the standardized plant extracts and phytoconstituents through several routes of drug administration. Only a few natural drugs have been through several routes of drug administration. Only a few natural drugs have been applications of phytosomes numerous studies are undergoing and lots more is expected in the forthcoming years. The techniques used for such formulations are expected in the forthcoming years. The techniques used for such formulations are patentable and highly profitable.
Keywords:
- Absorption
- Bioavailability
- Phytoconstituents
- Phytosomes
- Stability.
How to Cite
Anupama Singh, Manjeet Singh, Anil Bhandari, & Vikas Anand Saharan. (2011). Phytosome: Drug Delivery System for Polyphenolic Phytoconstituents: Phytosome. Iranian Journal of Pharmaceutical Sciences, 7(4), 209–219. https://doi.org/10.22037/ijps.v7.41292
References
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[29] Kohli K, Ali J, Ansari M, Raheman Z. Curcumin:a natural anti-inflammatory agent. Ind J Pharmacol 2005; 37: 141-7.
[30] Maiti K, Mukherjee K, Gantait A, Saha B, PK M.Enhanced therapeutic potential of naringeninphospholipid complex in rats.J Pharm Pharmacol 2006; 58:1227-33.
[31] Semalty A, Semalty M, Singh R, Saraf S, Saraf S. Development and characterization of phytosomes of novel xanthones isolated alternifolia for improving the bioavailability.AAPS Annual Meeting and Exposition 2007;PAGES.
[32] Esculin (esculoside, asculin). Available at http://www.bpg.bg/substances/esculin.phtml:Accessed on 21st April 2011.
[33] Guang-xi Z, Hongxiang L, Dianzhou B.Interaction of puerarin with phospholipid in solid dispersion. Chin Pharm J 2003; 12: 36-40.
[34] Chang Y, Hsieh C-Y, Peng Z-A, Yen T-L, Hsiao G, Chou D-S, Chen C-M, Sheu J-R. Neuroprotective mechanisms of puerarin in middle cerebral artery occlusion-induced brain infarction in rats.J Biomed Sci 2009; 16: 9.
[35] Li Y, Pan W, Chen S, Xu H, Yang D, ASC C. Pharmacokinetic,tissue distribution, and excretion of puerarin and puerarin-phospholipid complex in rats. Drug Dev Ind Pharm 2006; 32: 413-22.
[36] Li Y, Yang D-J, Chen S-L, Chen S-B, Chan ASC.Process parameters and morphology in puerarin, phospholipids and their complex microparticles generation by supercritical antisolvent precipitation. Internat J Pharm 2008; 359: 35-45.
[37] House J. Antioxidants (proanthocyanidins).Available at http://www.ounceofprevention.com/wow/pycnogen.htm: Accessed on 21st April 2011.
[2] Kumar P, Yadav S, Agarwal A, Kumar N.Phytosomes: a noval phyto-phospholipid carriers: an overview. Int J Pharm Res Dev 2010; 2:(6): Article No. 9 Available at www.ijprd.com/PHYTOSOMES_%20A%NOVAL%PHYTO-PHOSPHOLIPID% CARRIERS_%AN%OVERVIEW.pdf.
[3] Sharma S, Roy R. Phytosomes: an emerging technology. Int J Pharm Res Dev 2010; 2: PAGES Available at www.ijprd.com/PHYTOSOMES %20_%AN%EMERGING%TECHNOLOGY.pd.
[4] Kidd P. Phospholipids: versatile nutraceuticals for functional foods. Functional Ingredients 2002; December:NUMBER: PAGES Available at http://archive.functionalingredientsmag.com/articl e/Ingredient-Focus/phospholipids-versatilenutraceutical-ingredients-for-functional-.aspx.
[5] Pandey S, Patel K. Phytosomes: technical revolution in phytomedicine. Int J Pharm Tech Res 2010; 2: 627-31.
[6] Schmitt H. Lecithin and phospholipids - healthy and natural powerful nutrients. Wellness Foods Europe 2008; NUMBERJune/July: 24-9.
[7] Product-Information. Nefful's anti-aging skin supplement-a natural skin regimen, the need for a natural antiaging skin regimen. Available at http://www.neffulusa.com/downloads/pdf/2009/A
R_Ingredient_Information.pdf: Accessed on 21st April 2011.
[8] Product brochures, indena. Available at http://www.indena.com/pages/brochures.php:Accessed on 21st April 2011.
[9] Bhattacharya S. Phytosomes: the new technology for enhancement of bioavailability of botanicals and nutraceuticals. Int J Health Res 2009; 2: 225-9.
[10] Vasanti M. Phytosomes: a short review. Biol Online 2008; NUMBER: PAGES
[11] Patel J, Patel R, Khambholja K, Patel N. An overview of phytosomes as an advanced herbal drug delivery system. Asian J Pharm Sci 2009; 4:363-71.
[12] Franceschi F, Giori A. Phospholipid complexes of olive fruits or leaves extracts having improved bioavailability. Indena Spa, Milano, Italy 2007, Patent No. WO 2007/118631.
[13] Giori A, Franceschi F. Phospholipid complexes of curcumin having improved bioavailability. Indena Spa, Milano, Italy 2007, Patent No. WO 2007/101551.
[14] Morazzoni P, Bombardelli E. Phospholipid complexes prepared from extracts of Vitis vinifera as anti-atherosclerotic agents. Indena Spa, Milan, Italy 2001, Patent No. US6297218.
[15] Bombardelli E, Morazzoni P. Phospholipid complexes of proanthocyanidin a2 as antiather osclerotic agents. Indena Spa, Milan, Italy 2002,Patent No. US 6429202.
[16] Bombardelli E. Oral compositions for the treatment of cellulite. Indena Spa, Milano, Italy 2010, Patent No. US 7691422.
[17] Gabetta B, Bombardelli, Ezio, Pifferi, Giorgio.Complexes of flavanolignanes with phospholipids, preparation thereof and associated pharmaceutical compositions. Inverni, Della Beffa Spa, Italy
1987, Patent No. EP 0209038.
[18] Bombardelli E, Patri, Gian Franco, Pozzi, Roberto. Complexes of saponins with phospholipids and pharmaceutical and cosmetic compositions containing them. Indena Spa, Milano, Italy 1988,
Patent No. EP 0283713.
[19] Bombardelli E, Patri GF. Complex compounds of bioflavonoids with phospholipids, their preparation and use, and pharmaceutical and cosmetic compositions containing them. Indena Spa, Milano, Italy 1993, Patent No. EP 0275005.
[20] Bombardelli E, Patri G, Pozzi R. Complexes of neolignane derivatives with phospholipids, the use thereof and pharmaceutical and cosmetic formulations containing them. Indena Spa, Milano, Italy 1992, Patent No. EP 0464297.
[21] Bombardelli E, Mustich G. Bilobalide phospholipide complexes, their applications and formulations containing them. Indena Spa, Milano, Italy 1991, Patent No. EP 0441279.
[22] Silybin-phosphatidylcholine complex. Altern Med Rev 2009; 14: 385-90.
[23] Tedesco D, Tedesco D SS, Galletti S, Tameni M,Sonzogni O, Ravarotto L. Efficacy of silymarinphospholipid complex in reducing the toxicity of aflatoxin b1 in broiler chicks. Poult Sci 2004;83: 1839-43.
[24] Farinacci M, Gaspardo B, Colitti M, Stefanon B. Dietary administration of curcumin modifies transcriptional profile of genes involved in inflammatory cascade in horse leukocytes. Italian J Animal Sci 2009; 8: 84-6.
[25] Di Pierro F, Menghi A, Barreca A, Lucarelli M, Calandrelli A. Greenselect®phytosome as an adjunct to a low-calorie diet for treatment of obesity: a clinical trial. Alt Med Rev 2009; 14: 15460.
[26] Naik S, Pilgaonkar V, Panda V. Evaluation of antioxidant activity of ginkgo biloba phytosomes in rat brain. Phytotherapy Res 2006; 20: 1013-6.
[27] Complimentary medicines summary: Echinacea.Uk medicines information. 2002; Available at http://www.ukmi.nhs.uk/Med_info/documents/Ec hinaceaCMS.pdf: Accessed on 21st April 2011.
[28] Bombardeli E, Bonati A, Gabetta B, Mustich G.Triterpenoids of terminalia sericea.Phytochemistry 1974; 13: 2559-62.
[29] Kohli K, Ali J, Ansari M, Raheman Z. Curcumin:a natural anti-inflammatory agent. Ind J Pharmacol 2005; 37: 141-7.
[30] Maiti K, Mukherjee K, Gantait A, Saha B, PK M.Enhanced therapeutic potential of naringeninphospholipid complex in rats.J Pharm Pharmacol 2006; 58:1227-33.
[31] Semalty A, Semalty M, Singh R, Saraf S, Saraf S. Development and characterization of phytosomes of novel xanthones isolated alternifolia for improving the bioavailability.AAPS Annual Meeting and Exposition 2007;PAGES.
[32] Esculin (esculoside, asculin). Available at http://www.bpg.bg/substances/esculin.phtml:Accessed on 21st April 2011.
[33] Guang-xi Z, Hongxiang L, Dianzhou B.Interaction of puerarin with phospholipid in solid dispersion. Chin Pharm J 2003; 12: 36-40.
[34] Chang Y, Hsieh C-Y, Peng Z-A, Yen T-L, Hsiao G, Chou D-S, Chen C-M, Sheu J-R. Neuroprotective mechanisms of puerarin in middle cerebral artery occlusion-induced brain infarction in rats.J Biomed Sci 2009; 16: 9.
[35] Li Y, Pan W, Chen S, Xu H, Yang D, ASC C. Pharmacokinetic,tissue distribution, and excretion of puerarin and puerarin-phospholipid complex in rats. Drug Dev Ind Pharm 2006; 32: 413-22.
[36] Li Y, Yang D-J, Chen S-L, Chen S-B, Chan ASC.Process parameters and morphology in puerarin, phospholipids and their complex microparticles generation by supercritical antisolvent precipitation. Internat J Pharm 2008; 359: 35-45.
[37] House J. Antioxidants (proanthocyanidins).Available at http://www.ounceofprevention.com/wow/pycnogen.htm: Accessed on 21st April 2011.
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