Ameliorative effect of allopurinol on cisplatin-induced memory impairment in male Wistar rat Ameliorative effect of allopurinol on cisplatin-induced memory impairment
Iranian Journal of Pharmaceutical Sciences,
Vol. 18 No. 1 (2022),
15 January 2022
,
Page 35-45
https://doi.org/10.22037/ijps.v18.41361
Abstract
Neurotoxicity is an adverse effect of chemotherapy drugs on the central nervous system. Many studies have demonstrated that xanthine oxidase inhibitors prevent the formation of reactive oxygen species (ROS). The present study aimed to investigate the effects of allopurinol as an oxidase inhibitor on the learning and memory impairment induced by cisplatin. This study was conducted on 40 male Wistar rats, which were randomly divided into five groups, as follows: 1) control injected with saline (1 ml/kg/i.p); 2) cisplatin (5 mg/kg/once a week; i.p.); 3) allopurinol (ALP; 50 mg/kg/once a week; P.O.); 4) Cis+ALP 50 (cisplatin 5 mg/kg/i.p and allopurinol 50 mg/kg/once a week; P.O.) and 5) Cis+ALP 100 (cisplatin 5 mg/kg/i.p and allopurinol 100 mg/kg/once a week; P.O.). Drugs were administered for five weeks in all groups. The interval between administrations of drugs were half an hour. Morris water maze (MWM) was used to evaluate the memory and learning of the animals. The tissue brain concentrations of malondialdehyde (MDA), thiol, and superoxide dismutase (SOD) were measured using biochemical tests. According to the results, the cisplatin group had longer escape latency and shorter time spent and traveled pathway in the target quadrant compared to the control group. On the other hand, allopurinol treatment significantly reversed the results of the spatial memory test. The biochemical data indicated that cisplatin increased MDA concentration but decreased thiol and SOD activity compared to the control group. Administration of allopurinol decreased the MDA level but increased the thiol levels in the cortex and hippocampus tissues. Therefore, it was concluded that allopurinol could improve cisplatin-induced memory impairment by affecting the oxidative status of the brain tissue.
Keywords:
- Allopurinol,
- Cisplatin,
- Memory,
- Malondialdehyde,
- Thiol,
- Superoxide dismutase.
How to Cite
Masoud Hosseinzadeh, Samad Nazemi, Omid Gholami, Marzieh Kafami, Mohammad Keyvanloo Shahrestanaki, & Akbar Peghhan. (2022). Ameliorative effect of allopurinol on cisplatin-induced memory impairment in male Wistar rat: Ameliorative effect of allopurinol on cisplatin-induced memory impairment. Iranian Journal of Pharmaceutical Sciences, 18(1), 35–45. https://doi.org/10.22037/ijps.v18.41361
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[5] Fanelli M, Tavanti E , Pia Patrizio M, Vella S, Fernandez-Ramos A, Magagnoli F, Luppi S, Hattinger CM and Serra M. Cisplatin Resistance in Osteosarcoma: In vitro Validation of Candidate DNA Repair-Related Therapeutic Targets and Drugs for Tailored Treatments. Front. Oncol. (2020) 10(331): 187-93.
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[12] Kart A, Cigremis Y, Karaman M and Ozen H. Caffeic acid phenethyl ester (CAPE) ameliorates cisplatin-induced hepatotoxicity in rabbit. Exp. Toxicol. Pathol. (2010) 62(1): 45-52.
[13] Manohar S, Jamesdaniel S and Salvi R. Cisplatin inhibits hippocampal cell proliferation and alters the expression of apoptotic genes. Neurotox. Res. (2014) 25(4): 369-80.
[14] Zainal A, Faisal I and Ahmad A. Biomarkers of iron status in allopurinoltreated renal stone patients. Pharmacia. (2021) 68(3): 633–642.
[15] Goicoechea M,Vinuesa S, Verdalles U, Ruiz-Caro C, Ampuero J, Rincón A, Arroyo D and Luno J. Effect of Allopurinol in Chronic Kidney Disease Progression and Cardiovascular Risk. Clin. J. AM. Soc. Nephrol. (2010) 5(8): 1388–1393.
[16] Fairbanks L, Cameron J, Venkat‐Raman G, Rigden S, Rees L, Van'T Hoff W, Mansell M, Pattison J, Golsmitt DJA and Simmonds HA. Early treatment with allopurinol in familial juvenile hyerpuricaemic nephropathy (FJHN) ameliorates the long‐term progression of refkafaminal disease. Qjm. (2002) 95(9): 597-607.
[17] Thanassoulis G, Brophy JM, Richard H and Pilote L. Gout, allopurinol use, and heart failure outcomes. Arch. Intern. Med. (2010) 170(15): 1358-64.
[18] Choi E, Jung H, Kwak K, Yeo J, Yi S, Park C, Ryu TH, Jeon YH, Park KM and Lim DG. Effects of allopurinol and apocynin on renal ischemia-reperfusion injury in rats. Transplant. Proc. (2015) Elsevier.
[19] Ferrando B, Olaso-Gonzalez G, Sebastia V, Viosca E, Gomez-Cabrera MC and Viña J. Allopurinol and its role in the treatment of sarcopenia. Rev. Esp.
Geriatr. Gerontol. (2014) 49(6): 292-8.
[20] Safari Sultan Abad A, Falanji F, Ghanbarabadi M, Rad A, Nazemi S, Pejhan A and Amin B. Assessment of anti-nociceptive effect of allopurinol in a neuropathic pain model. Brain. Res. (2019) 1720: 146238.
[21] Rodríguez-Fanjul J, Durán Fernández-Feijóo C, Lopez-Abad M, Lopez Ramos MG, Balada Caballé R, Alcántara-Horillo S and Camprubi M. Neuroprotection with hypothermia and allopurinol in an animal model of hypoxic-ischemic injury: Is it a gender question? PLoS One. (2017)12(9): e0184643.
[22] Yamaguchi M, Okamoto K, Kusano T, Matsuda Y, Suzuki G, Fuse A and Yokota H. The effects of xanthine oxidoreductase inhibitors on oxidative stress markers following global brain ischemia reperfusion injury in C57BL/6 mice. PLoS One. (2015) 10(7): e0133980.
[23] Aminzadeh A. The effect of allopurinol on high glucose-induced neurotoxicity in PC12 cells. Sci. JKU.
Med. Sci. (2017) 22(1): 1-10.
[24] Lara DR, Cruz MR, Xavier F, Souza DO and Moriguchi EH. Allopurinol for the treatment of aggressive behaviour in patients with dementia. Int.
Clin. Psychopharmacol. (2003) 18(1): 53-5.
[25] Dong G, Ren M, Wang X, Jiang H, Yin X, Wang S, Wang X and Feng H. Allopurinol reduces severity of delayed neurologic sequelae in experimental carbon monoxide toxicity in rats. Neurotoxicology. (2015)48: 171-9.
[26] Oz M, Atalik KEN, Yerlikaya FH and Demir EA. Curcumin alleviates cisplatin-induced learning and memory impairments. Neurobiol. Learn.Mem. (2015)123: 43-9.
[27] Margaritis EV, Yanni AE, Agrogiannis G, Liarakos N, Pantopoulou A, Vlachos I, Papachristodoulouc A, Korkolopoulou P, Patsouris E, Kostakis M, Perrea DN and Kostakis A. Effects of oral administration of l-arginine, l-NAME and allopurinol
on intestinal ischemia/reperfusion injury in rats. Life. Sci. (2011) 88(23-24): 1070-6.
[28] Bavarsad K, Hadjzadeh M, Hosseini M, Pakdel R, Beheshti F, Bafadam S and Ashaari Z. Effects of levothyroxine on learning and memory deficits in a rat model of Alzheimer's disease: the role of BDNF and oxidative stress. Drug Chem. Toxicol. (2020) 43(1): 57-63
[29] Alaei H, Moloudi R, Sarkaki AR, Azizi-Malekabadi H and Hanninen O. RETRACTED: Daily running promotes spatial learning and memory in rats. Elsevier. (2007) 14(2): 105-8.
[30] Monteiro SC, Matté C, Bavaresco CS, Netto CA, Wyse AT. Vitamins E and C pretreatment prevents ovariectomy-induced memory deficits in water maze. Neurobiol. Learn. Mem. (2005)84(3): 192-9.
[31] Hosseini M, Shafei MN, Safari V, Taiarani Z, Kafami Ladani M and Sadeghian R. The effects of olibanum administered to methimazole-treated dams during lactation on learning and memory of offspring rats. Nat. Prod. Res. (2012) 26(16): 1544-8.
[32] Kafami M, Hosseini M, Niazmand S, Farrokhi E, Hajzadeh MA-R and Nazemi S. The effects of estradiol and testosterone on renal tissues oxidative after central injection of angiotensin II in female doca–salt treated rats. Horm. Mol. Biol. Clin. Investig. (2018) 37(3).
[33] Madesh M and Balasubramanian K. Microtiter plate assay for superoxide dismutase using MTT reduction by superoxide. Indian J. Biochem. Biophys. (1998) 35(3): 184-8.
[34] Shojaei A, Shabani M, Pilevarian A, Parsania S and Razavinasab M. Effect of Acute administration of Cisplatin on memory, motor learning, balance and explorative behaviours in Rats. Physiol. Pharmacol. (2012) 16(2): 121-35.
[35] Chen C, Zhang H, Xu H, Zheng Y, Wu T and Lian Y. Ginsenoside Rb1 ameliorates cisplatin-induced learning and memory impairments. J. Ginseng Res. (2019) 43(4): 499-507.
[36] Waseem M and Parvez S. Mitochondrial dysfunction mediated cisplatin induced toxicity: modulatory role of curcumin. Food Chem. Toxicol. (2013) 53: 334-42.
[37] Sen S, De B, Devanna N and Chakraborty R. Cisplatin-induced nephrotoxicity in mice: protective role of Leea asiatica leaves. Ren. fail. (2013) 35(10): 1412-7.
[38] Choi S, Kim S, Lee J, Lim H, Kim Y, Tian C, So HS, Park R and Choung YH. Gingko biloba extracts protect auditory hair cells from cisplatin-induced ototoxicity by inhibiting perturbation of gap junctional intercellular communication. Neuroscience. (2013) 244: 49-61.
[39] Song TY, Chen CL, Liao JW, Ou HC and Tsai MS. Ergothioneine protects against neuronal injury induced by cisplatin both in vitro and in vivo. Food Chem.Toxicol. (2010) 48(12): 3492-9.
[40] Minami T, Ichii M and Okazaki Y. Detection of Platinum in the Brain of Mice Treated with Cisplatin and Subjected to Short‐term Hypoxia. J. Pharm. Pharmacol. (1996) 48(5): 505-9.
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