Anti-Acne Gel of Quercetin Loaded Niosomes
Iranian Journal of Pharmaceutical Sciences,
Vol. 21 No. 1 (2025),
21 January 2025
,
Page 271-281
https://doi.org/10.22037/ijps.v21i1.46120
Abstract
We aimed to create a gel to treat acne. It contains quercetin-loaded niosomes. The thin film hydration method formulated quercetin-loaded niosomes made of cholesterol, maltodextrin, and span 60. The best batch of niosomes showed entrapment efficiency (97.10±0.10%), particle size (62.37±2µm), zeta potential (-43.4±6mv), and polydispersity index of 0.0554. The best batch (F7) was composed of quercetin (50 mg), Span 60 (180 mg), cholesterol (20 mg), maltodextrin (120 mg), hydration time (120 s), and hydration volume (30 ml). Further, F7 was subjected to a sonicator to reduce the particle size to 593.5±2.0 nm. Niosomes with spherical shapes were evenly dispersed, as shown by SEM analysis. Next, using a cold mechanical technique, quercetin niosomes loaded gel was prepared using carbopol 940. Gel exhibited a pH of 6.4, a high viscosity of 12,500 cP, quercetin diffusion through goat skin (93.56±2.19% within six h), and a zone of inhibition against Cutibacterium acnes (5.2± 0.9 mm). In conclusion, niosomal gel loaded with quercetin was thus shown to be a viable delivery strategy to treat acne.
- Niosomes
- Quercetin
- Niosomal gel
- Propionibacterium acnes
How to Cite
References
Alanazi MS, Hammad SM, Mohamed AE. Prevalence and psychological impact of Acne vulgaris among female secondary school students in Arar city, Saudi Arabia, in 2018. Electron. Physician. (2018) 10(8):7224-7229.
Geng R, Sibbald RG. Acne vulgaris: Clinical aspects and treatments. Adv. FSkin & Wound Care. (2024)1; 37(2):67-75.
Motosko CC, Zakhem GA, Pomeranz MK, Hazen A. Acne: a side‐effect of masculinizing hormonal therapy in transgender patients. Br. J. Dermatol. (2019) 1; 180 (1):26-30.
Wadhwa K, Kadian V, Puri V, Bhardwaj BY, Sharma A, Pahwa R, Rao R, Gupta M, Singh I. New insights into quercetin nano-formulations for topical delivery. Phytomed. Plus. (2022) 1; 2 (2):100257.
McLaughlin J, Watterson S, Layton AM, Bjourson AJ, Barnard E, McDowell A. Propionibacterium acnes and acne vulgaris: new insights from the integration of population genetic, multi-omic, biochemical and host-microbe studies. Microorganisms. (2019) 13; 7 (5):128.
Fournière M, Latire T, Souak D, Feuilloley MG, Bedoux G. Staphylococcus epidermidis and Cutibacterium acnes: two major sentinels of skin microbiota and the influence of cosmetics. Microorganisms. (2020) 7; 8 (11):1752.
Ramasamy S, Barnard E, Dawson Jr TL, Li H. The role of the skin microbiota in acne pathophysiology. Br. J. Dermat. (2019) 1;181(4):691-9.
Kutlu Ö, Karadağ AS, Wollina U. Adult acne versus adolescent acne: a narrative review with a focus on epidemiology to treatment. An. Bras. Dermatol. (2023) 98 (1):75-83.
Dessinioti C, Katsambas AD. The role of Propionibacterium acnes in acne pathogenesis: facts and controversies. Clinics in Dermatology. (2010) 28 (1), 2-7.
Qidwai A, Pandey M, Pathak S, Kumar R, Dikshit A. The emerging principles for acne biogenesis: a dermatological problem of puberty. Hum. Microbiome J. (2017) 1; 4:7-13.
Lim HJ, Kang SH, Song YJ, Jeon YD, Jin JS. Inhibitory effect of quercetin on propionibacterium acnes-induced skin inflammation. Int. Immunopharmacol. (2021) 1; 96:107557.
Makrantonaki E, Ganceviciene R, Zouboulis CC. An update on the role of the sebaceous gland in the pathogenesis of acne. Dermatoendocrinol. (2011) 1; 3(1):41-9.
Tanghetti EA. The role of inflammation in the pathology of acne. J. Clin. Aesthet. Dermatol. (2013) 6(9):27.
Alexeyev OA, Dekio I, Layton AM, Li H, Hughes H, Morris T, Zouboulis CC, Patrick S. Why we continue to use the name Propionibacterium acnes. Br. J. Dermatol. (2018) 1; 179(5).
Kawabata K, Mukai R, Ishisaka A. Quercetin and related polyphenols: new insights and implications for their bioactivity and bioavailability. Food funct. (2015) 6(5):1399-417.
Nguyen TL, Bhattacharya D. Antimicrobial activity of quercetin: an approach to its mechanistic principle. Molecules. (2022) 12; 27(8):2494.
Zhang M, Swarts SG, Yin L, Liu C, Tian Y, Cao Y, Swarts M, Yang S, Zhang SB, Zhang K, Ju S. Antioxidant properties of quercetin. In Oxygen transport to tissue XXXII. Springer US. (2011) 283-289.
Almatroodi SA, Alsahli MA, Almatroudi A, Verma AK, Aloliqi A, Allemailem KS, Khan AA, Rahmani AH. Potential therapeutic targets of quercetin, a plant flavonol, and its role in the therapy of various types of cancer through the modulation of various cell signaling pathways. Molecules. (2021) 1; 26 (5):1315.
Saeedi-Boroujeni A, Mahmoudian-Sani MR. Anti-inflammatory potential of Quercetin in COVID-19 treatment. J. Inflamm. (2021) 18:1-9.
Osonga FJ, Akgul A, Miller RM, Eshun GB, Yazgan I, Akgul A, Sadik OA. Antimicrobial activity of a new class of phosphorylated and modified flavonoids. ACS omega. (2019) 30; 4(7):12865-71.
Jaisinghani RN. Antibacterial properties of quercetin. Microbiol. Res. (2017) 2; 8(1):6877.
Lim HJ, Kang SH, Song YJ, Jeon YD, Jin JS. Inhibitory effect of quercetin on propionibacterium acnes-induced skin inflammation. Int. Immunopharmacol. (2021) 1; 96:107557.
Vijay K. Toll-like receptors in immunity and inflammatory diseases: Past, present, and future. Int. Immunopharmacol. (2018) 1; 59:391-412.
Plaper A, Golob M, Hafner I, Oblak M, Šolmajer T, Jerala R. Characterization of quercetin binding site on DNA gyrase. Biochem. Biophys. Res. Commun. (2003) 27; 306(2):530-6.
Zhao L, Chen J, Bai B, Song G, Zhang J, Yu H, Huang S, Wang Z, Lu G. Topical drug delivery strategies for enhancing drug effectiveness by skin barriers, drug delivery systems and individualized dosing. Front. Pharmac. (2024) 16;14:1333986.
Budhiraja A, Dhingra G. Development and characterization of a novel antiacne niosomal gel of rosmarinic acid. Drug deliv. (2015) 18; 22(6):723-30.
Jufri M, Muthaharrah MU, Humairah EL, Purwaningsih EH. Stability of anti-acne niosome gels containing betel leaf (Piper betle L.) essential oil. Int. J. Appl. Pharm. (2017) 130-4.
Kazi KM, Mandal AS, Biswas N, Guha A, Chatterjee S, Behera M, Kuotsu K. Niosome: a future of targeted drug delivery systems. J. Adv. Pharm. Technol. Res. (2010) 1; 1(4):374-80.
Uchegbu IF, Florence AT. Non-ionic surfactant vesicles (niosomes): physical and pharmaceutical chemistry. Advances in colloid and interface science. 1995 Jun 27;58(1):1-55.
Uchegbu IF, Vyas SP. Non-ionic surfactant based vesicles (niosomes) in drug delivery. Int. J. Pharm. (1998) 172, (1–2), 33-70.
A-sasutjarit R, Sirivat A, Vayumhasuwan P. Viscoelastic properties of Carbopol 940 gels and their relationships to piroxicam diffusion coefficients in gel bases. Pharm. Res. (2005); 22(12):2134-40.
Banyi Lu, Yanting Huang, Zhongyun Chen, Jingyi Ye, Hongyu Xu, Wenrong Chen, Xiaoying Long. Niosomal nanocarriers for enhanced skin delivery of quercetin with functions of anti-tyrosinase and antioxidant. Molecules. (2019) 24(12): 2322.
I Handojo.The combined use of topical benzoyl peroxide and tretinoin in the treatment of acne vulgaris. Int. J. Dermatol. (1979) 18(6):489-96.
Yasamineh S, Yasamineh P, Kalajahi HG, Gholizadeh O, Yekanipour Z, Afkhami H, Eslami M, Kheirkhah AH, Taghizadeh M, Yazdani Y, Dadashpour M. A state-of-the-art review on the recent advances of niosomes as a targeted drug delivery system. Int. J. Pharm. (2022) 25;624:121878.
Mohanty D, Rani MJ, Haque MA, Bakshi V, Jahangir MA, Imam SS, Gilani SJ. Preparation and evaluation of transdermal naproxen niosomes: formulation optimization to preclinical anti-inflammatory assessment on murine model. J. Liposome Res. (2020) 1; 30(4):377-87.
Javani R, Hashemi FS, Ghanbarzadeh B, Hamishehkar H. Quercetin-loaded niosomal nanoparticles prepared by the thin-layer hydration method: Formulation development, colloidal stability, and structural properties. LWT. (2021) 1; 141:110865.
Mohanty D, Rani MJ, Haque MA, Bakshi V, Jahangir MA, Imam SS, Gilani SJ. Preparation and evaluation of transdermal naproxen niosomes: formulation optimization to preclinical anti-inflammatory assessment on murine model. J. Liposome Res. (2020) 1; 30 (4):377-87.
Budhiraja A, Dhingra G. Development and characterization of a novel antiacne niosomal gel of rosmarinic acid. Drug deliv. (2015) 18; 22(6):723-30.
Abdelkader H, Ismail S, Kamal A, Alany RG. Preparation of niosomes as an ocular delivery system for naltrexone hydrochloride: physicochemical characterization. Die Pharmazie- Int. J. Pharm. Sci. (2010) 1; 65(11):811-7.
Bhardwaj P, Tripathi P, Gupta R, Pandey S. Niosomes. A review on niosomal research in the last decade. J. Drug Del. Sci. Tech. (2020) 1;56:101581.
Elmi N, Ghanbarzadeh B, Ayaseh A, Sahraee S, Heshmati MK, Hoseini M, Pezeshki A. Physical properties and stability of quercetin loaded niosomes: stabilizing effects of phytosterol and polyethylene glycol in orange juice model. J. Food Eng. (2021) 1; 296:110463.
Kazi KM, Mandal AS, Biswas N, Guha A, Chatterjee S, Behera M, Kuotsu K. Niosome: a future of targeted drug delivery systems. J. Adv. Pharm. Technol. Res. (2010) 1; 1(4):374-80.
Shirsand SB, Para MS, Nagendrakumar D, Kanani KM, Keerthy D. Formulation and evaluation of ketoconazole niosomal gel drug delivery system. Int. J. Pharm. Investig. (2012) 2(4):201.
Lin YK, Hsiao CY, Alshetaili A, Aljuffali IA, Chen EL, Fang JY. Lipid-based nanoformulation optimization for achieving cutaneous targeting: Niosomes as the potential candidates to fulfill this aim. Eur. J. Pharm. Sci. (2023) 1; 186:106458.
Ravalika V, Sailaja AK. Formulation and evaluation of etoricoxib niosomes by thin film hydration technique and ether injection method. Nano. Biomed. Eng. (2017) 1; 9(3):242-8.
Pandit AP, Omase SB, Mute VM. A chitosan film containing quercetin-loaded transfersomes for treatment of secondary osteoporosis. Drug Deliv. Transl. Res. (2020) 10:1495-506.
Khazaeli P, Pardakhty A, Shoorabi H. Caffeine-loaded niosomes: characterization and in vitro release studies. Drug Deliv. (2007) 1; 14(7):447-52.
Barot T, Rawtani D, Kulkarni P. Development, characterization and in vitro–in vivo evaluation of Farnesol loaded niosomal gel for applications in oral candidiasis treatment. Heliyon. (2021) 1; 7(9).
Owodeha-Ashaka K, Ilomuanya MO, Iyire A. Evaluation of sonication on stability-indicating properties of optimized pilocarpine hydrochloride-loaded niosomes in ocular drug delivery. Progress Biomat. (2021)10:207-20.
Van der Koog L, Gandek TB, Nagelkerke A. Liposomes and extracellular vesicles as drug delivery systems: A comparison of composition, pharmacokinetics, and functionalization. Adv. Healthc. Mater. (2022) 11(5):2100639.
Dubey A, Prabhu P, Kabrawala H, Ghate V. Niosomal gel of adapalene: its formulation, physicochemical properties and evaluation for mild-acne. Adv. Biomed. Pharma. (2015) 2(1):22-31.
Goyal MK, Qureshi J. Formulation and evaluation of itraconazole niosomal gel for topical application. J. Drug Deliv. Ther. (2019) 25; 9(4-s):961-6.
Waqas MK, Sadia H, Khan MI, Omer MO, Siddique MI, Qamar S, Zaman M, Butt MH, Mustafa MW, Rasool N. Development and characterization of niosomal gel of fusidic acid: In-vitro and ex-vivo approaches. Des. Monomers Polym. (2022) 31;25(1):165-74.
Zaid Alkilani A, Hamed R, Abdo H, Swellmeen L, Basheer HA, Wahdan W, Abu Kwiak AD. Formulation and evaluation of azithromycin-loaded niosomal gel: optimization, in vitro studies, rheological characterization, and cytotoxicity study. ACS Omega. (2022) 25;7(44):39782-93.
Prakash C, Bhargava P, Tiwari S, Majumdar B, Bhargava RK. Skin Surface pH in Acne Vulgaris: Insights from an Observational Study and Review of the Literature. J Clin Aesthet Dermatol. (2017) 1;10(7):33–39.
Moammeri A, Chegeni MM, Sahrayi H, Ghafelehbashi R, Memarzadeh F, Mansouri A, Akbarzadeh I, Abtahi MS, Hejabi F, Ren Q. Current advances in niosomes applications for drug delivery and cancer treatment. Materials Today Bio. (2023) 23, 100837.
Goyal, G, Garg, T, Malik, B, Chauhan, G, Rath, G, Goyal, AK. Development and characterization of niosomal gel for topical delivery of benzoyl peroxide. Drug delivery, (2015) 22(8): 1027-1042.
Han SB, Kwon SS, Jeong YM, Yu ER, Park SN. Physical characterization and in vitro skin permeation of solid lipid nanoparticles for transdermal delivery of quercetin. Int. J. Cosmet. Sci. (2014) 36(6):588-97.
Kajbafvala A, Salabat A, Salimi A. Formulation, characterization, and in vitro/ex vivo evaluation of quercetin-loaded microemulsion for topical application. Pharm. Dev. Technol. (2018) 14; 23(8):741-50.
Chellathurai BJ, Anburse R, Alyami MH, Sellappan M, Bayan MF, Chandrashekharan B, Chidambaram K, Rahamthulla M. Development of a polyherbal topical gel for the treatment of acne. Gels. (2023), 9(2):163.
Azeem M, Hanif M, Mahmood K, Ameer N, Chughtai FR, Abid U. An insight into anticancer, antioxidant, antimicrobial, antidiabetic and anti-inflammatory effects of quercetin: A review. Polym. Bull. (2023) 80(1):241-62.
- Abstract Viewed: 303 times
- IJPS_Volume21_Issue1_Pages271-281 Downloaded: 269 times